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These are preclinical, cell-based observations, and experimental outcomes depend on intracellular NAD+/NADH ratios, compartmentalisation and the metabolic state of the model system
Importantly, excessive B12 intake is not harmful, as the body excretes any surplus it doesn't need
It is not applicable in routine human clinical practice
A third recommends 3mL for easier dosing
Stress, responsibilities, health conditions, and lifestyle habits play a significant role
However, evaluation of the intestinal barrier in clinical studies is usually limited to the assessment of the paracellular permeability
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